Drug resistance in microbes is a predictable outcome of exposure to drugs, but some U of T research may modify that outcome. Doctoral student Leah Cowen is lead author of a study into the genetic changes in the much-maligned yeast Candida albicans – a common inhabitant of healthy humans that causes thrush, diaper rash and vaginal infections, as well as life-threatening infections in immuno-compromised individuals – when exposed to an anti-fungal drug. Researchers grew more than 330 generations of the yeast in the presence of the anti-fungal drug fluconazole. Drug resistance increased as predicted. Changes in hundreds of genes were noted, with altered genes displaying three distinct patterns. Recognizing these patterns will make it easier for scientists to target drug therapy, Cowen says.
Recent Posts
U of T’s Feminist Sports Club Is Here to Bend the Rules
The group invites non-athletes to try their hand at games like dodgeball and basketball in a fun – and distinctly supportive – atmosphere
From Mental Health Studies to Michelin Guide
U of T Scarborough alum Ambica Jain’s unexpected path to restaurant success
A Blueprint for Global Prosperity
Researchers across U of T are banding together to help the United Nations meet its 17 sustainable development goals