In principle, a well-designed and well-documented experiment will accurately describe a real phenomenon and provide other researchers with everything they need to reproduce those results in a comparable study.
To replicate an experiment, researchers use the same methods of data collection and apply the same analysis, even though they have to use new subjects, often in somewhat different situations. Subjects may be generally older or younger, for example, or from a different country.
While later tests can’t possibly be identical to the original, they need to be similar enough to yield comparable data.
Concepts like “similar enough” and “comparable data” involve a level of subjectivity that adds to the controversy around replication. When a study fails a replication attempt, defenders often question whether the followup truly reflected the original. Researchers help to resolve such debates when they openly share their data and methods.
By bringing artificial intelligence into chemistry, Prof. Aspuru-Guzik aims to vastly shrink the time it takes to develop new drugs – and almost everything else