In December 2021, U of T launched its new campaign, Defy Gravity. Its twin goals: to inspire 225,000 alumni to become involved with the university for the first time; and to raise $4 billion for the university’s highest priorities. In this issue, we highlight the immense possibility of this new campaign: By bringing together talented people from every conceivable background, What if we could prevent future pandemics? What if we could build robots for almost any purpose? What if we could speed up the pace of scientific discovery? Plus: professor Fiona Rawle’s culture of kindness, how to save an endangered language, and much more.